ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Fingers predict prostate cancer

Since their discovery, we learned that the microglia immune status is often correlated directly to their morphology. However, only recently, have we realized that, in vivo microglia are extremely dynamic cells capable to respond within minutes. Therefore, the name resting microglia is replaced slowly with surveilling microglia.

These may be related to the role played by epithelial-mesenchymal transition EMT and cancer stem cells in endometrial carcinogenesis. In this context, our review highlights the prognostic significance of several types of myoinvasion in low grade, low stage endometrioid endometrial carcinoma, as a reflection of these molecular changes at the invasive front.

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According to recently introduced myoinvasive patterns, the diffusely infiltrating and microcystic, elongated, and fragmented MELF patterns show loss of hormone receptors, along with EMT and high expression of cancer stem cell markers, being associated with a poor prognosis. Additionally, MELF pattern exhibits a high incidence of lymphovascular invasion and lymph node metastases. Conversely, the broad front pattern has a good prognosis and a low expression of EMT and stem cells markers.

Similarly, the adenomyosis AM -like and adenoma malignum patterns of invasion are associated to a favorable prognosis, but nevertheless, they raise diagnostic challenges.

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AM-like pattern must be differentiated from carcinoma invasion of AM foci, while adenoma malignum pattern creates difficulties in appreciating the depth of myoinvasion and requires differential diagnosis with other conditions.

Another pattern expecting its validation and prognostic significance value is the nodular fasciitis-like stroma and large cystic growth pattern.

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In practice, the knowledge of these patterns of myoinvasion may be valuable for the correct assessment of stage, may improve prognosis evaluation and may help identify molecules for future targeted therapies.

The role of tumor microenvironment in development and progression fingers predict prostate cancer malignant melanomas - a systematic review Simona Gurzu, Marius Alexandru Beleaua, Ioan Jung To reveal the particular aspects of the tumor microenvironment of malignant melanomas, a systematic review including 34 representative papers was performed.

The possible reversible features of EMT and the role of tumor microenvironment in the metastatic process were also analyzed. As the McSCs embryological development in mouse is not similar to human development, the role of stem cells in genesis and development of human melanoma should be proved in human melanoma cells only. For further development of targeted therapy, fingers predict prostate cancer better understanding of melanomagenesis pathways and its microenvironment particularities is necessary.

Immunohistochemistry predictive markers for primary colorectal cancer tumors: where are we and where are we going? We reviewed articles that examined CRC samples with significant statistic correlation between the IHC marker expression and disease progression over time, relationships with the available clinical features and those who detect the prognosis of drug effects. Our analysis showed that nine markers could correlate with medical treatment response of CRCs in different stages.

When using better overall survival OS and better disease-free survival DFS as a grouping factor, there were 14 markers that could be used in assessing CRC prognosis. Subgroup analysis was also performed based on the 32 markers recently confirmed to predict metastasis evolution or the recurrence risks. Venous invasion could be predictable for tumors, statistically significant metastasis susceptibility was observed for markers and also the capacity to evaluate recurrence.

CRCs integrate a variety of localizations and there are proofs that distinguish the sites of tumors. The studies reporting data specifically for rectal cancer separating it from colon cancer contained seven IHC markers.

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In order to be able to implement a predictive biomarker in clinical practice, it must comply with certain criteria as clinical value and analytical proof.

Unique biological signature of CRC can be distinguished by identifying biomarkers expression. Several markers have shown potential, but the majority still need to render clinical utility.

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The prostatic cellular and molecular kaleidoscope. Starting points for carcinogenesis Andrei Daniel Timofte, Irina-Draga Caruntu The prostate cancer is a heterogeneous disorder concealing different phenotypical and functional subtypes of cancer cells.

This heterogeneity mirrors the normal prostate cell lineages whose alterations represent the starting points of the carcinogenesis mechanism. The histological structure of the prostate comprises two main types of cells: epithelial and stromal, with a stromal to epithelial ratio of The prostate acini are lined by a fingers predict prostate cancer layer composed of four different subtypes of epithelial cells: secretory luminal, basal, neuroendocrine, and transit-amplifying.

The epithelial component is enclosed in a stromal tissue, consisting of several types of cells: smooth muscle cells the most numerous cell typefibroblasts, and myofibroblasts. Despite their quite similar morphological appearance in light microscopy, the molecular markers expressed by the normal epithelial and stromal prostatic components, as well as the stem cells show that the prostatic cells are not equal.

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Consequently, several hypotheses regarding the location and the phenotype of these cells were formulated and tested, mainly in animal models. The molecular mapping of normal human prostate tissue might be the key for unlocking the intricate mechanisms of prostate carcinogenesis. Within this context, the prostatic cancer stem cells are thought to play an important role in tumor initiation, progression, recurrence and also therapy resistance.

The cancerous phenotype of a stem cell can be reached via multiple genetic trajectories and epigenetic alterations, resulting in different subclonal populations of cancer stem cells, thus explaining the heterogeneity of the prostatic neoplasia.

Future efforts should be directed towards better understanding of the relationship and interactions between these cancer stem cells subpopulations, their microenvironments, and also towards characterizing the signaling pathways and molecules involved in the regulation of prostatic cancer stem cells.

Cancer and aggressive behaviour

The results of these studies could offer a different, more comprehensible perspective for a new, molecular classification of prostate cancer, overlapping the existing histological one. Starting points for carcinogenesis PDF 6. It was revealed that mixing with alloying elements, such as Mn and Zn, provides improved corrosion resistance to Mg alloys; this pursuit is built on the fact that Mg and its alloys are degradable through their time in the human body.

Furthermore, Mg alloys afford a characteristic profile that is very close or even almost identical to that of human bone.

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Minimizing the rate of fingers predict prostate cancer of Mg is the most adequate method, because a low corrosion rate of an Mg implant involves a decrease in the extent lumanari din cartofi pentru prostatita hydrogen evolution and alkalization, which allow the human body to gradually absorb or consume the corrosion products.

In those situations, both clinical and paraclinical findings might orientate the diagnosis, but only histological or immunohistochemistry changes might be accurate enough. The skin histological changes are relevant and sometimes might have a tremendous role in the accurate diagnosis of autoimmune rheumatic diseases, due to the correlation with the clinical systemic manifestations of the diseases and through the accessibility of biopsy.

In the same time, muscle biopsy can provide important support for physicians improving diagnosis and optimizing management of connective tissue diseases.

prostate cancer — Traducere în română - TechDico

Fingers predict prostate cancer between morphological changes induced by curcumin and its biological activities Laura Stoica, Bogdan Alexandru Stoica, Doinita Olinici, Pavel Onofrei, Emanuela Ana Botez, Carmen Elena Cotrutz Curcumin is a phytochemical polyphenol extracted from turmeric rhizome, with multiple biological activities, intensively studied in various therapeutic areas. Its effects covers a wide range of specialties, from the neuroprotective to the antimetastatic properties, influencing pathologies from cardiovascular, neuronal and oncological fields, as a part of its broad spectrum of action.

These effects are explained by antioxidant, anti-inflammatory and anticarcinogenic simultaneous roles of curcumin and its derivatives.

In this review, we selected the information about morphological evidences correlated with the biological effects on the following fingers predict prostate cancer fingers predict prostate cancer the central nervous system including neurological pathology, such as Parkinson s and Alzheimer s diseasethe cardiovascular system including disorders like atherosclerosis, endothelial dysfunction and drug-induced myotoxicitymultiple forms of cancer, and metabolic syndromes including diabetes.

The central point of this review was magician 30 cu prostatita target a variety of morphological changes at microscopic level induced by curcumin, using different microscopy techniques.

Hyaluronic acid-based scaffolds for tissue engineering Cristina Chircov, Alexandru Mihai Grumezescu, Ludovic Everard Bejenaru Hyaluronic acid HA is a natural glycosaminoglycan found in the extracellular matrix of most connective tissues.

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Due to its chemical structure, HA is a hydrophilic polymer and it is characterized by a fast degradation rate. HA-based scaffolds for tissue engineering are intensively studied due to their increased biocompatibility, biodegradability and chemical modification. Depending on the processing technique, scaffolds can be prepared in the form of hydrogels, sponges, cryogels, and injectable hydrogels, all discussed in this review.

Sepsis is one of the most common diseases, which cause mortality and a considerable absorber of healthcare resources. Despite progress in technology and improving knowledge of pathophysiology, the disease mechanism is still poorly understood. At present, diagnosis is based on non-specific physiological criteria and on the late identification of the pathogen.

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For these reasons, the diagnosis may be uncertain, treatment delayed or an immunomodulatory therapy cannot be established. An early and reliable diagnosis is essential to achieve better outcomes on disease progression.

Cancer and aggressive behaviour Rolul genei p53 în prevenirea cancerului de sân Prof. Viermi pe măsură ce apar Probleme actuale privind aplicarea protocolului de tratament în cancerul de rect Supporters and Sponsors Probleme actuale privind aplicarea protocolului de tratament în cancerul de rect Rolul vierme fluture p53 în prevenirea cancerului de sân - Revista Română de Medicina Familiei Media Partners Cancer and aggressive behaviour, Actual problems regarding the implementation of the treatment protocol in rectal cancer Inoperable rectal tumour, no metastases: A radio-chemotherapy with a favourable response surgery B radio-chemotherapy with a non-favourable response chemotherapy Operable rectal tumour, with cancer and aggressive behaviour radical surgery of the tumour with resection of the hepatic or lung metastasis radio-chemotherapy radio-chemotherapy followed by surgical treatment. Capsulă enterică Testosterone - Traducere în română - exemple în engleză Reverso Context Cancer and aggressive behaviour Anunță-mă prin e-mail despre comentariile ce urmează.

The host response to infection involves hundreds of many mediators of which have been proposed as biomarkers. There is a need for new diagnostic approaches for sepsis, new sepsis biomarkers that can aid in diagnosis, therapeutic decision and monitoring of the response to therapy.

The differentiation of sepsis from non-infectious systemic inflammatory response syndrome is difficult, and the search for a highly accurate biomarker of sepsis has become one important objective of the medicine. The goal of our review is to summarize the recent advances on the most commonly studied serum biomarkers, evaluated in clinical and experimental studies, for early diagnosis of sepsis and their informative value in diagnosis, prognosis, or response to therapy.

In this context, we have tracked the clinical utility of measuring serum biomarkers, such as procalcitonin, pro- and anti-inflammatory cytokines, C-reactive protein, leptin and their combinations. Currently, has not been identified an ideal biomarker to aid in the diagnosis of sepsis. It is hoped that the discovery of new serum markers, as well as their combinations, will serve for the diagnosis and prognosis of sepsis.

Patients, Materials and Methods: Seventeen patients were enrolled after rigorous criteria. Echocardiography was performed in conventional and speckle-tracking mode, in all patients with DCM, in sinus rhythm.